Stroke Medicine: What's on the Horizon for 2021?

In this podcast, Neurology Learning Network's Stroke & Vascular Section Editor Amrou Sarraj, MD, discusses anticipated developments this year in the areas of thrombolysis, thrombectomy, neuroprotection, stroke prevention, and more.

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Amrou Sarraj, MD, is an associate professor of neurology at McGovern Medical School at UTHealth in Houston, Texas.

References:

  1. SELECT 2: A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke. ClinicalTrials.gov. Published March 15, 2019. Updated October 16, 2019. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03876457. https://clinicaltrials.gov/ct2/show/NCT03876457
  2. The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke (TESLA). ClinicalTrials.gov. Published January 15, 2019. Updated February 28, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03805308. https://clinicaltrials.gov/ct2/show/NCT03805308
  3. Large Stroke Therapy Evaluation (LASTE). ClinicalTrials.gov. Published January 22, 2019. Updated September 25, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03811769. https://clinicaltrials.gov/ct2/show/NCT03811769
  4. Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window (Tension). ClinicalTrials.gov. Published March 29, 2017. Updated July 31, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03094715. https://clinicaltrials.gov/ct2/show/NCT03094715
  5. Endovascular treatment of acute ischemic stroke in the Netherlands for late arrivals. ISRCTN registry. Assigned December 11, 2017. Updated Febuary 16, 2021. Accessed February 16, 2021. ISRCTN identifier ISRCTN19922220. https://www.isrctn.com/ISRCTN19922220?q=&filters=conditionCategory:Circulatory%20System,recruitmentCountry:Netherlands&sort=&offset=3&totalResults=169&page=1&pageSize=10&searchType=basic-search
  6. Minor Stroke Therapy Evaluation (MOSTE). ClinicalTrials.gov. Published January 8, 2019. Last updated September 17, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03796468. https://clinicaltrials.gov/ct2/show/NCT03796468
  7. Endovascular Therapy for Low NIHSS Ischemic Strokes (ENDOLOW). ClinicalTrials.gov. Published November 19, 2019. Last updated February 8, 2021. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT04167527. https://clinicaltrials.gov/ct2/show/NCT04167527
  8. Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke (SWIFT DIRECT). ClinicalTrials.gov. Published June 20, 2017. Updated November 23, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03192332. https://clinicaltrials.gov/ct2/show/NCT03192332
  9. Is intravenous alteplase still of added benefit in patients with acute ischaemic stroke who undergo intra-arterial treatment?. ISRCTN registry. Assigned November 9, 2017. Updated February 16, 2021. Accessed February 16, 2021. ISRCTN identifier ISRCTN80619088. https://www.isrctn.com/ISRCTN80619088?q=&filters=conditionCategory:Nervous%20System%20Diseases,ageRange:Adult,recruitmentCountry:Netherlands&sort=&offset=5&totalResults=62&page=1&pageSize=10&searchType=basic-search
  10. Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). ClinicalTrials.gov. Published June 8, 2017. Updated January 22, 2021. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03181360. https://clinicaltrials.gov/ct2/show/NCT03181360
  11. Tenecteplase in Stroke Patients Between 4.5 and 24 Hours (TIMELESS). ClinicalTrials.gov. Published December 24, 2018. Updated April 13, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03785678. https://clinicaltrials.gov/ct2/show/NCT03785678
  12. Multi-arm Optimization of Stroke Thrombolysis (MOST). ClinicalTrials.gov. Published November 8, 2018. Updated May 6, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03735979. https://clinicaltrials.gov/ct2/show/NCT03735979
  13. BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit (BEST-MSU). ClinicalTrials.gov. Published July 15, 2014. Updated September 2, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT02190500. https://clinicaltrials.gov/ct2/show/NCT02190500
  14. Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (TASTEa). ClinicalTrials.gov. Published August 28, 2019. Updated September 24, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT04071613. https://clinicaltrials.gov/ct2/show/NCT04071613
  15. Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM). ClinicalTrials.gov. Published August 12, 2016. Updated February 5, 2021. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT02864953. https://clinicaltrials.gov/ct2/show/NCT02864953
  16. AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke (ARCADIA). ClinicalTrials.gov. Published June 20, 2017. Updated October 27, 2020. Accessed February 16, 2021. ClinicalTrials.gov identifier NCT03192215. https://clinicaltrials.gov/ct2/show/NCT03192215